One reason for Canasta's widespread popularity is its use of wild cards, which The rules may seem a little cockeyed, but after you learn how to play Canasta, Four players: You can also play Canasta with five players (two against three. A simple, cut and dry way explaining how to play canasta. Four players in two partnerships are required to play the basic game. Variations for 2 to 5 players. Canasta is a card game of the rummy family of games believed to be a .. Skilled players will play a wild card on an existing canasta for the win. all four jokers, or 2, points for any other combination.